Trey and Davidson Fulminant hepatic failure: development of HE within 8 weeks of onset of symptoms

England^*

Acute liver failure (includes only patients with encephalopathy)

Sub-classification depending on the interval between jaundice and HE:

Hyper-acute liver failure: 0 to 7 days Acute liver failure: 8 to 28 days Sub-acute liver failure: 29 to 72 days Late-onset acute liver failure: 56 to 182 days

France^**

Acute hepatic failure: a rapidly developing impairment of liver function Severe acute hepatic failure: prothrombin time or factor V concentration below 50% of normal with or without HE Sub-classification:

Fulminant hepatic failure: HE within 2 weeks of onset of jaundice Sub-fulminant hepatic failure: HE between 3 and 12 weeks of onset of jaundice

International Association for the Study of the Liver^***

Acute liver failure (occurrence of HE within 4 weeks after onset of symptoms)

Sub-classification:

Acute liver failure—hyper-acute: within 10 days Acute liver failure—fulminant: 10 to 30 days Acute liver failure—not otherwise specified Sub-acute liver failure (development of ascites and/or HE from 5 to 24 weeks after onset of symptoms)